NOXXON Pharma Announces Upcoming Oral Presentation at 2021 Society for Neuro-Oncology Annual Meeting


NOXXON Pharma SA (Euronext Growth Paris: ALNOX), a biotechnology company focused on improving cancer treatments by targeting the tumor microenvironment (TME), announces that new data from the ongoing GLORIA Phase I / II trial in brain cancer will be presented by the Dr. Frank Giordano, principal investigator of the study, in an oral presentation at the annual meeting of the Society for Neuro-Oncology. The meeting will take place in Boston, Massachusetts, United States, from November 18-21, 2021.

The details of the oral presentation are as follows:

Title: Inhibition of CXCL12 in Unmethylated MGMT Glioblastoma – Results of an Early Proof of Concept Assessment in the Multicenter Phase I / II GLORIA Trial (NCT04121455)

Session title: Session summary: Clinical trials I

Date of the session: Friday, November 19, 2021

Presentation time: 5:00 p.m. – 5:05 p.m. EST / 11:00 a.m. – 11:05 p.m. CET

Presenter: Dr Frank Giordano, Director and Chairman of the Radiation Oncology Department at the University Hospital Bonn, Germany

The embargo for abstracts published in the 2021 Abstract Supplement of the Official Journal of SNO Neuro-Oncology will be lifted at 7:00 a.m. EST on Thursday, November 11, 2021 and the abstract will be available at:

To register for the event, please click here.

A copy of the presentation will be available at NOXXON website shortly after the event.


NOXXON’s oncology-focused pipeline acts on the tumor microenvironment (TME) and the cancer immunity cycle by breaking down the tumor protective barrier and blocking tumor repair. By neutralizing the chemokines in TME, NOXXON’s approach works in combination with other forms of treatment to weaken tumor defenses against the immune system and allow greater therapeutic impact. NOXXON’s main program, NOX-A12, provided the final revenue data of a Keytruda® combined trial in patients with metastatic colorectal and pancreatic cancer published at the ESMO conference in September 2020 and July 2021, the company announced its phase 2 study, OPTIMUS, to further assess safety and efficacy NOX-A12 in combination with Keytruda from Merck® and two different chemotherapy regimens as second-line treatment in patients with metastatic pancreatic cancer. NOXXON is also studying NOX-A12 in brain cancer in combination with radiation therapy, which has been granted orphan drug status in the US and EU for the treatment of certain brain cancers. GLORIA, a trial of NOX-A12 in combination with radiotherapy in patients with newly diagnosed brain cancer who will not clinically benefit from standard chemotherapy, provided interim data from the first two cohorts showing consistent tumor reductions and objective tumor responses. The company’s second clinical-stage active, NOX-E36, is a phase 2 TME active targeting the innate immune system. NOXXON plans to test NOX-E36 in patients with solid tumors. Further information can be found at:

Keytruda® is a registered trademark of Merck Sharp & Dohme Corp

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About the GLORIA study

GLORIA (NCT04121455) is the phase 1/2 dose escalation study of NOXXON of NOX-A12 in combination with irradiation in patients with first-line glioblastoma (brain cancer) with a non-MGMT promoter. methylated (resistant to standard chemotherapy).

About the OPTIMUS study

OPTIMUS (NCT04901741) is NOXXON’s open-label, two-arm phase 2 study of NOX-A12 in combination with pembrolizumab and nanoliposomal irinotecan / 5-FU / leucovorin or gemcitabine / nab-paclitaxel in patients with ‘stable microsatellite metastatic pancreatic cancer.


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